| abstract |
The invention relates to novel compounds which act has anti-mycobacterial properties, in particular anti-tuberculosis. The novel molecules of AM1, AM2, AM3, AM4, AM5, AM6, AM7, AM8, AM9, AM10, AM11, AM12, AM13, AM14, AM15, AS1, AS2, AS3, AS4, AS5, AS6, AS7, AS8, AS9, AS10, AS11, AS12, AS13 and AS14 are of substituted Mannich base and Schiff base which contains anti-tuberculosis properties. The invention presents the method for preparation of compounds AM1, AM2, AM3, AM4, AM5, AM6, AM7, AM8, AM9, AM10, AM11, AM12, AM13, AM14 and AM15, wherein the steps includes: (a) s synthesizing an aromatic ester derivative using an aromatic carboxylic acid and alcohol in the presence of concentrated sulfuric acid; (b) synthesizing an acid hydrazide derivative using the aromatic ester derivative from step (a); (c) synthesizing Schiff bases using the acid hydrazide derivative from step (b); and (d) synthesizing Mannich bases using the Schiff bases from step (c). The present invention presents the method for preparation of compounds AS1, AS2, AS3, AS4, AS5, AS6, AS7, AS8, AS9, AS10, AS11, AS12, AS13 and AS14, wherein the steps includes: (a) synthesizing an aromatic ester derivative using an aromatic carboxylic acid and alcohol in the presence of concentrated sulfuric acid; (b) synthesizing an acid hydrazide derivative using the aromatic ester derivative from step (a);and (c) synthesizing Mannich bases using the Schiff bases from step (b). |