| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f398f038d89b1e57c85178ec42cf4c8b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_03785b3e90a7085de9491f460ec47460
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b09f893b262cefd50c5e76c4b85d1c0a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_375dcb75e25d369574b45c1e305287d8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_626735826472dd62cd826351adb8a0ae
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_683b50e847b6915f6c8b998c379fdf04 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K17-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06086
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-062
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08F112-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-068 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K17-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-04 |
| filingDate |
2011-10-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_61f98862c31bdcb73dde1a23cf1953e0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_663e51d542f5d4f7b9a4d9855882df1a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9371b56a03f9612d4cc9120964fb9f9d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_58d4e74c1b20e7268ee0826bc129b62e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_74238a15cb50f5172c0194762ba2508d |
| publicationDate |
2012-05-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2012055509-A1 |
| titleOfInvention |
Diketopiperazine forming dipeptidyl linker |
| abstract |
The invention relates to a method for homogeneous solution phase peptide synthesis (HSPPS) of a N-terminal peptide fragment PEP-N and a C-terminal peptide fragment C-PEP, with C- PEP carrying a specific diketopiperazine (DKP) comprising C-terminal protecting group, which contains a handle group HG, with HG being connected to the C-terminus of the peptide fragment; thereby this specific DKP comprising C-terminal protecting group can be selectively cleaved from the peptide as a conventionally used C-terminal protecting group. By the use of this DKP and HG comprising C-terminal protecting group, certain process steps in convergent peptide synthesis based on a combination of HSPPS and solid phase peptide synthesis (SPPS) can be avoided. The invention relates further to a method for the preparation of such specifically protected fragment C-PEP by SPPS by using a linker comprising a specific dipeptide and HG for connecting the growing peptide chain to the resin, which linker forms said DKP group, when the peptide fragment C-PEP is cleaved from the supporting resin; and further to the intermediates of the preparation method. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10450343-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10087221-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105218405-A |
| priorityDate |
2010-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |