| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8e071d18fea054bf8d1420d483e78ed1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3b76892bbb7efd8fd7eb3dba463e5c11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_696ac31bb3024bffaefdfa0ad34156e1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ed23a826197e8364652da468ec61f45a |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C271-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C311-07
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D261-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C237-26 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C311-07
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D261-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-165
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 |
| filingDate |
2011-10-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c7359eeea5133ccc466887ff26d186b7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0e94d9c3b77114bbf213d9536c07c3b6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7b4835732c833dcc57b462974ed7dac0 |
| publicationDate |
2012-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2012047907-A9 |
| titleOfInvention |
Synthesis of c5-substituted tetracyclines, uses thereof, and intermediates thereto |
| abstract |
The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The recent development of a modular synthesis of tetracycline analogs through a chiral enone intermediate has allowed for the efficient synthesis of novel tetracycline analogs never prepared before. The present invention provides more efficient routes for preparing the enone intermediate and allows for a wide variety of substituents at position 5 of the tetracycline ring system. |
| priorityDate |
2010-10-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |