| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_11d9f084e0e5d0c30d732a778fbccc3f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_aea57db10fe6e572d4a54808447081e9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7728ed8d5b2145bf472c799d5c1b0c6a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_284013255bca0610cad351f904c1d504 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-41
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-105
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-335
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2506-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-119
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-415
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-385
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-606
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-603
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-604
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-602
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2502-1323
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2510-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-39
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0676 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-12 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-074
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-39 |
| filingDate |
2011-09-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_599876ca227baf4877d6580a41344dee
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1ae553cabf7943b77baabb20705b34eb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_421c87e526c2941e839204c296596411 |
| publicationDate |
2012-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2012044486-A1 |
| titleOfInvention |
Induction of pancreatic stem cells by transient overexpression of reprogramming factors and pdxi selection |
| abstract |
Methods for generating pancreatic stem cells from a pancreatic tissue of 24-week old mice by transient overexpression of reprogramming factors combined with Pdxl selection is described herein. The generated cells were designated as iPaS (induced pancreatic stem) cells and exhibit the same morphology as the pancreatic stem cells previously established from young donors without genetic manipulation and express genetic markers of endoderm and pancreatic progenitors. Transplantation of the iPaS cells into nude mice resulted in no teratoma formation. Moreover, iPaS cells were able to differentiate into insulin-producing cells more efficiently than ES cells. In addition, the technology of transient overexpression of reprogramming factors and tissue-specific selection of the present invention may also be useful for the generation of other tissue-specific stem cells. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11760977-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2020089313-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11685901-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3611255-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3739041-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2017512472-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015148832-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9546379-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10912800-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2015235922-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3578643-A1 |
| priorityDate |
2010-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |