| abstract |
The present invention pertains to the field of modified neurotoxin polypeptides. In particular, it relates to a polynucleotide encoding a neurotoxin polypeptide comprising at least two neurotoxin light chains and a heavy chain. The neurotoxin polypeptide encoded by the polynucleotide exhibits, in an aspect, a prolonged duration of the biological effect in a subject. Moreover, contemplated are a vector and a host cell which comprise the polynucleotide as well as a neurotoxin polypeptide encoded by the aforementioned polynucleotide. Further, the present invention relates to a medicament comprising the polynucleotide, the vector or the neurotoxin polypeptide and its therapeutic and cosmetic applications. |