abstract |
The present invention provides targeted delivery compositions and their methods of use in treating and diagnosing a disease state in a subject. In one aspect, the targeted delivery compositions of the present invention can include a targeted delivery compositon, comprising: (a) a nanocarrier including a therapeutic or diagnostic agent or a combination thereof; and (b) a conjugate having the formula: A- [(EG) (P)]n-T; wherein, A is an attachment component for attaching the conjugate to the nanocarrier; [(EG) (P)]n is a linking group, wherein the subscript n is an integer from 1 to about 40; and each EG is independently selected from a group consisting of triethylene glycol, tetraethylene glycol, pentaethylene glycol, hexaethylene glycol, heptaethylene glycol, and octaethylene glycol; P is independently selected from a group consisting of phosphate and thiophosphate; and, T is a targeting agent. |