| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_de0de5cbd9036f59e24c185dd112ab68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7738b1e17825d455ee6960292c66231b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f8c0982b0f02b1ed6d20a315370a3a3a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1b34cdcc462e6acdbbfd002b81be13f5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_17ad420e2cfc4648cb181c03c92509ab |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-575
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-67 |
| filingDate |
2011-09-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7a4dd5d01d77610147b732de26268f72
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_359b359df8fb2ad1e48987cdffe432dd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6824b145262230193c6ba7635309244b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_042858aa3617dcfd2d76c86530299a3c |
| publicationDate |
2012-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2012039954-A2 |
| titleOfInvention |
Reliable stabilization of n-linked polypeptide native states with enhanced aromatic sequons located in polypeptide tight turns |
| abstract |
A chimeric therapeutic polypeptide of a pre-existing therapeutic polypeptide is disclosed, as are a method of enhancing folded stabilization and a pharmaceutical composition of the glycosylated chimer. The pre-existing and chimeric polypeptides have substantially the same length, substantially the same amino acid residue sequence, and exhibit at least one tight turn containing a sequence of four to about seven amino acid residues in which at least two amino acid side chains extend on the same side of the tight turn and are within less than about 7Å of each other. The chimeric therapeutic polypeptide has the sequon Aro- (Xxx) n - ( Zzz ) p -Asn-Yyy-Thr/Ser [SEQ ID NO:___] within that tight turn sequence such that the side chains of the Aro, Asn and Thr/Ser amino acid residues project on the same side of the turn and are within less than about 7Å of each other. That sequon is absent from the pre-existing therapeutic polypeptide. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10988512-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3426785-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109790545-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11203626-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2017230792-B2 |
| priorityDate |
2010-09-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |