| abstract |
The invention is directed to chimeric measles virus - retrovirus particles, i.e., measles virus (MV) particles expressing the envelope proteins of a retrovirus, or immunogenic regions thereof, at its surface. The present invention provides means, in particular nucleic acids, vectors, cells and rescue systems to produce and to culture these chimeric particles. The invention also relates to the use of these chimeric particles, in particular under the form of a composition or of a vaccine, for the treatment or prevention of retrovirus infection, following induction of cellular and/or humoral immune response(s). |