http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012035406-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_47c1537834d70c6d6f4503291b1ad766 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_71321ff1a1eeda093fcc3972306efe21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6181a278ca43c5774c9b855d223f442d http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_114e4423ec77cbc8dab9d0a98909704e http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a7dd0c9f470642cdb2f088e7c2bb5e44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dbe2b6b6d528dbf2e8d8f1607b827c0c |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-16 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4045 |
| filingDate | 2011-09-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_06e88dcf779715f44b19cabebbdc3e7c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f40a8966d8111d9a1ebc7fec50b5a05f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5c7b36d532386655cfaace18b8706384 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f5c26b2f82d3d25c7e703eab0f77aa4b |
| publicationDate | 2012-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2012035406-A1 |
| titleOfInvention | Tryptamine derivatives, their preparation and their use in gastropathy |
| abstract | The present invention concerns the synthesis and evaluation of gastroprotective effect of different tryptamine derivatives. Tryptamine derivatives have been synthesized by formation of amide or ester with some known anti oxidant molecules. These derivatives show excellent antioxidant property in vitro. Among all the derivatives the compound SEGA (3 a), that was prepared by the combination of serotonin with gallic acid shows the greater antioxidant property than the other synthesized compounds both in vivo and in vitro. SEGA(3a) shows the gastroprotective effect against NSAIDs (indomethacin or diclofenac)-induced gastropathy in dose dependent manner and also accelerates the healing from injury. It prevents the NSAIDs-induced mitochondrial oxidative stress in vivo. This derivative prevents NSAID-induced mitochondrial oxidative stress-mediated apoptosis in vivo by preventing the activation of caspase 9 and caspase-3 and restores NSAIDs-mediated collapse of mitochondroial transmembrane potential and dehydrogenase activity. SEGA (3 a) plays an important role as an iron chelator as well as intra mitochondrial ROS scavenger. Thus, SEGA (3 a) is a potent antioxidant antiapototic molecule, which efficiently prevents NSAID-induced gastropathy and stress or alcohol -mediated gastric damage. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20160124373-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-102439852-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113880749-A |
| priorityDate | 2010-09-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 277.