| abstract |
The objective of the present invention is to provide a bitter-drug-containing powdered medicine or granular medicine and an orally disintegrating tablet that achieve both suppression of bitterness in the oral cavity and superior dissolution in the stomach. The drug-containing granules, which comprise (a) core particles containing the bitter drug and (b) a masking coating film that coats the core particles, are characterized by the masking coating film containing at least one excipient selected from D-mannitol, lactose, trehalose, xylitol, maltitol, and erythritol, and at least one polymer selected from a methacrylate copolymer (S), a methacrylate copolymer (L), a methacrylate/ethyl acrylate copolymer, an ethyl acrylate/methyl methacrylate copolymer, or the like. |