| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d9f50d3b05852222aa0d4c179a1e0e40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_20ab1e3ff48cf1807fdd57afbec71c27
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_994d1034e8cc636d2029b05fc7aa2ed2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_639c6b2415345b14bd644f7cea2b92da |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-435
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-17 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 |
| filingDate |
2011-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6b4a4c109ae35887fdf1819f5397e0e8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ccc9389ee4c75169583482e5bb8ad5cc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f49af8442ff293d8556b23c79262becf |
| publicationDate |
2012-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2012020289-A2 |
| titleOfInvention |
Specific active site inhibitors of enzymes or substrate binding partners and methods of producing same |
| abstract |
The present disclosure provides a method of producing enzyme- specific inhibitors or substrate binding partners comprising: identifying active site residues of the substrate in the enzyme substrate complex or in substrate binding partner-substrate complex; randomizing the active site residues to produce a combinatorial library of substrate variants; and selecting substrate variants that inhibit enzyme activity or bind substrate as substrate-specific binding partners. The present disclosure also provides ubiquitin enzyme specific inhibitors and ubiquitin variants that bind ubiquitin interaction motifs. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018164573-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023049421-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2015520730-A |
| priorityDate |
2010-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |