| abstract |
The present invention relates to a method of treating, preventing or inhibiting parasitic disease, in particular leishmaniasis or trypanosomiasis in a subject, by a compound of formula (1): R 2 -A-R 1 wherein: - A represents a group chosen from a phenyl, a triazolyl, and a thienyl, - R 1 represents -CO-CH 2 OH or -CO-NHOH, - R 2 is chosen from H, triazolyl, methyltriazolyl, -CONHR 3 , -CH 2 -CONHR 3 , - 'NHS0 2 NHR 3 , -CH 2 -NHSO 2 NHR 3 , wherein R 3 represents H, a (C 1 -C 8 ) alkyl group, an aryl group, a (C 3 -C 8 ) cycloalkyl group, a heterocyclic group, or a heteroaryl group. Or a pharmaceutically acceptable salt thereof. |