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filingDate 2011-07-07-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_875305e496e642bcaeef7f94400bba06
publicationDate 2012-01-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2012008361-A1
titleOfInvention Method for introducing nucleic acid to cell and nucleic acid complex
abstract Provided is a method for introducing a nucleic acid to a cell, and also provided is a nucleic acid complex used in the method. The method for introducing a nucleic acid to a cell comprises a step for forming a nucleic acid complex by bringing a double-stranded nucleic acid molecule into contact with a nucleic acid carrier, which has a peptide chain that forms a β-sheet structure in which a side chain of a basic amino acid having a positive charge is disposed on one surface side and a side chain of a hydrophobic amino acid is disposed on the opposite surface side, in the presence of a double-stranded nucleic acid molecule having a double helix structure and an amino acid sequence that alternates between a basic amino acid and a hydrophobic amino acid, and by joining the double-stranded nucleic acid molecule and the peptide chain by way of the electrostatic interaction between the side chains of the basic amino acid and phosphoric acid groups and also one or both hydrogen bonds.
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