| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8deb59d3e5c53df8388aa8a9067342a5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9d3509656bdb878f5f055351837bc3cd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_792709408a2aaa2945c430032f283be3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2f39d4f09b4f8d6932d175d03a409843
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8c6f0dcd23ea1260bb336aaa03883721 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-2821
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-302
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-304
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-2857
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-142
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-158
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-136
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-106
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-978
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-303 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6883
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5023 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate |
2011-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4bc2261f15128727c53e66937b2f5f8e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_45d0f86513f7090b701bc7fcd6f7bacf
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ea4621ced73e1fa4417a33d951d90909
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5f83b0778c43cac69beea815e3ebfd1f |
| publicationDate |
2011-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2011161253-A1 |
| titleOfInvention |
Editing profiling of pde8a pre -mrna : use as specific biomarker of adars activities in human tissues to diagnose and to predict and assess therapeutic efficacy and/or efficiency or potential drug side effects |
| abstract |
The present invention relates to the use of the editing profile of PDE8A pre-mRNA as a specific bio marker of ADARs activities in evolved primate, particularly in Human tissues. The present invention also relates to an in vitro method for predicting in Human an alteration of the mechanism of the ADARs catalysed pre-mRNA editing of target genes, by analysing the PDE8A pre-mRNA editing profile in a peripheral tissue sample containing cells expressing said PDE8A pre-mRNA, such as blood sample. The present invention is also directed to an in vitro method for the screening of potential therapeutic compound and to predict and assess therapeutic efficacy and/or efficiency or to diagnose potential severe brain or peripheral drug side effects implementing said PDE8A pre-mRNA editing profile as specific biomarker. The present invention is further directed to a method for determining the PDE8A pre-mRNA editing profile in Human, particularly by capillary electrophoresis single-strand conformation polymorphism (CE-SSCP) method after amplification by a nested PCR. Finally the invention relates to particular nucleic acid primers implemented in said nested PCR and kit comprising such sets of primers and human cells capable of expressing PDE8A and ADARs. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109642256-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017153849-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018020042-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108779494-A |
| priorityDate |
2010-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |