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filingDate 2011-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8e9b83a025bd97a693d0abd1a9114d01
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publicationDate 2011-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2011161165-A1
titleOfInvention Long-term storage of non-glycosylated recombinant human g-csf
abstract The present invention provides a method for stable long-term storage of non-glycosylated recombinant human G-CSF, wherein an aqueous acetate or glutamate buffered G-CSF composition containing the non-glycosylated recombinant human G-CSF and sorbitol is cooled to a temperature of -15°C or below to obtain a frozen G-CSF composition, which frozen composition is then stored in the frozen state and then increased in temperature to a temperature within the range of from 2°C to 8°C for a period of time adjusted to allow the composition to thaw and to obtain a liquid composition having a G-CSF content of at least 95% of the G-CSF content of the original composition.
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