| abstract |
Disclosed is a compound having both a PPAR activation action and an angiotensin receptor antagonistic action. Said compound is a benzo- or pyrido-imidazole derivative represented by expression (I) <img file="JPOXMLDOC01-appb-I000261.tif" he="25.1" img-format="tif" wi="165.0"/>, a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable ester or amide thereof. (In the expression, A is a biphenyl methyl-imidazolyl group, biphenyl methyl-benzimidazolyl group, etc.; B is a divalent benzimidazolyl group, etc.; C is a carboxyl group, etc.; E is a divalent phenyl group, naphthyl group, etc.; G is a dangling bond, an oxygen atom, etc.; Q is an oxygen or sulfur atom; n is an integer from 1 to 6, p is an integer from 1 to 6; V is a dangling bond, an oxygen atom, etc.; and R is a hydrogen atom, an alkyl group, etc.) |