| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7450f8b709a8f9c94070d7468a736d31
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3ec4fdcedaecb58a77276de7ece342b3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_91e2cb26955bbd751109d3c35b48a395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_29d0654592afcbcf089c679369443092
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bab6929dd09b2dc86a21bf347adc9559
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_58ec318005987b3f74d1a4ebf35247a0 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-321
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-533
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-323 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1135
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1138
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 |
| filingDate |
2011-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_001681db755781af8869b62494ceb4aa
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3451170f1b2c292a8c066ea4a68f95d2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e79b0943e2aa694a98a450ac2785c2fb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1ec91439d3a069885be7d0fa8efc129b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_69ec337057d1f178272c364a3773905d |
| publicationDate |
2011-11-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2011139842-A2 |
| titleOfInvention |
Nucleic acid compounds for inhibiting fgfr3 gene expression and uses thereof |
| abstract |
This disclosure provides double- stranded nucleic acid complexes having one or more hydroxymethyl substituted nucleomonomer(s) and wherein one strand is complementary to a FGFR3 mRNA. Nucleic acid complexes of the disclosure may be useful for therapeutic applications, diagnostic applications or research applications. Nucleic complexes include short interfering RNA complexes (siRNA) capable of modulating gene expression comprising an antisense strand and a continuous or a discontinuous passenger strand ("sense strand"). Further, one or more hydroxymethyl substituted nucleomonomer(s) of this disclosure may be positioned at the 3 '-end, at the 5 '-end, at both the 3 '-end and 5 'end, and/or in a double- stranded region of a nucleic acid complex. Also provided are methods of decreasing expression of a FGFR3 gene in a cell or in a subject to treat a FGFR3-related disease. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-102306656-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9725723-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11390871-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014080004-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10358647-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20150004748-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017106111-A1 |
| priorityDate |
2010-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |