| abstract |
Specific binding members, particularly antibodies and fragments thereof, which bind to Carbonic Anhydrase IX (CAIX) are provided, particularly including recognizing both human and mouse CAIX and blocking or inhibiting CAIX activity. These antibodies are useful in the diagnosis and treatment of cancer and in conditions associated with hypoxia and/or elevated CAIX activity. The anti-CAIX antibodies, variable regions or CDR domain sequences thereof, and fragments thereof may also be used in therapy in combination with chemotherapeutics, immune modulators, or anti¬ cancer agents and/or with other antibodies or fragments thereof. Antibodies of this type are exemplified by the novel antibodies MSC 1 through MSC 12 whose sequences are provided herein. |