| abstract |
Provided is a cephem compound represented by the following formula, having a broad antibacterial spectrum, and exhibiting strong antibacterial activity particularly with respect to β-lactamase producing gram-negative bacteria. Also provided is a pharmaceutical composition containing the same. Formula (I) : [In the formula, W and U are as described in the description, R 1 is as described in the description, and R 2 n A and R 2B are as described in the description. However, if R 1 is an aminothiadiazole or aminothiazole in which the amino group may be protected, R 2A and R 2B , rather than being oxime groups which may combine to have substituents, are 6-membered aromatic heterocyclic groups having 1 to 3 nitrogen atoms, and ring A is a benzene ring, R 3 is a hydrogen atom, -OCH 3 or -NH-CH(=O), k is an integer from 0 to 2, and R 4 is as described in the description. D and E are a) or b) as denoted in the description.] |