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filingDate 2011-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3da36a9e612d5781dd42e19aeea3baa2
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publicationDate 2011-11-03-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2011134672-A1
titleOfInvention Isotope production method
abstract The present invention relates to a method for the generation of 223 Ra of pharmaceutically tolerable purity comprising: i) preparing a generator mixture comprising 227 Ac, 227 Th and 223 Ra in a first aqueous solution comprising a first mineral acid; ii) loading said generator mixture onto a DGA separation medium (e.g. resin); iii) eluting said 223 Ra from said DGA separation medium using a second mineral acid in a second aqueous solution to give an eluted 223 Ra solution; and iv) stripping the DGA separation medium of said 227 Ac and 227 Th by flowing a third mineral acid in a third aqueous solution through the DGA separation medium in a reversed direction; The invention further relates to high purity radium-223 formed or formable by such a method as well as pharmaceutical compositions comprising such radium-223 of pharmaceutical purity.
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http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018153969-A1
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