| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9cfe5308b6e8e901fbb62d4c726c1647
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a33a756f2fbeb706009421ba25af95c8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_df597c3a3e85d1b236622b72c19a9d5e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_68c213ba9952360f439567152e047b18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5b2fa5db0decca0c52a3c0a7c2a116aa
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_aadae90a1bc0cd19e9a5fc4dd917293f |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-3181
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-33
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-15 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1138
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-111
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-90
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 |
| filingDate |
2011-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a6005522270881bfff80f8473b2d4ae7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b8093c9b019a79a52cb8aecc2821510b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c075bdd260486f02b7d4c62e3b072194
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2e40b13a283d22b54765378fdb64a579 |
| publicationDate |
2011-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2011133803-A1 |
| titleOfInvention |
Compositions and methods for targeted inactivation of hiv cell surface receptors |
| abstract |
Compositions for targeted mutagenesis of cell surface receptors for HIV and methods of their use are provided herein. The compositions include triplex-forming molecules that displace the polypyrimidine strand of target duplex and form a triple-stranded structure and hybrid duplex in a sequence specific manner with the polypurine strand of the target duplex. The triplex-forming molecules include a mixed-sequence "tail" which increases the stringency of binding to the target duplex, improves the frequency of modification at the target site, and reduces the requirement for a polypurine :polypyrimidine stretch. Methods for using the triplex-forming molecules in combination with one or more donor oligonucleotides for targeted modification of sites within or adjacent to genes that encodes cell surface receptors for human immunodeficiency virus (HIV) are also disclosed. Methods for ex vivo and in vivo prophylaxis and therapy of HIV infection using the disclosed compositions are also provided. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109476706-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020033951-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11136597-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018187493-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017143042-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017143042-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017143061-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020257776-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020257779-A1 |
| priorityDate |
2010-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |