| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_419b274e49a2979ec9e8312bec48e004
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_690bba5562ddc76386a629214e075cf0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_998c56188fc5fdacc6b6ee882c088c40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_be3be91fe9bf496e0a356c6aebbab434 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-178
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-141 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6883 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 |
| filingDate |
2011-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_be2eb218dc9e0258c21a6bb537c120b2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b0f4fb6efdccadc8e83a4b19cbcd7df4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_585c0ce7e348a0d40742f9c49920d2e3 |
| publicationDate |
2011-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2011131193-A1 |
| titleOfInvention |
Diagnosing and treating fibrotic diseases using micro-rna 17 |
| abstract |
This invention relates to the use of a specific micro-RNA (micro-RNA 17) to monitor disease activity and treat fibrotic disorders such as systemic sclerosis, cirrhosis of the liver, pulmonary sclerosis, retroperitoneal fibrosis and other conditions characterized by excessive pathological collagen accumulation (scarring) in tissues. The micro-RNA 17 is a specific 23 nucleotide single-stranded RNA molecule that is decreased in the circulation of patients with systemic sclerosis and which regulates key collagen telopeptide lysyl hydroxylases involved in pathological crosslinking of collagen. This makes it useful for diagnosing and monitoring fibrosis as well as the basis of drugs or other treatments that upregulate the levels of this miR in fibrosis patients. |
| priorityDate |
2010-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |