| abstract |
Disclosed is a modified oligonucleotide that can control the expression of a target gene with few side effects, such as induction of interferon and other cytokines, and a pharmaceutical composition containing that modified oligonucleotide. Specifically, the modified oligonucleotide can be a modified oligonucleotide that forms a flush end if forming a double-stranded chain and is capable of controlling the expression of a target gene. |