| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_751562df05f1831baef905641425c407
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fa58e252b04badcc3c2f05864e160cec
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0fe91e483ef230ba91ee109fbf86dd6e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e70d855e0fdddc6cb4c26347fd1e73ec
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_148851245ad27eccf46c1b46d58028a4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3438d2d9c6f1fe25e921e341a4c14542 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2458-15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2400-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2560-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B40-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B5-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5308
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B40-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B5-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16B40-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G06F17-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16B5-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-60 |
| filingDate |
2011-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_207a515817f490fdfeb4e428d987fb17
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2b23a8fb988d95833523c41d24da5ac4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_53a605601377e0b566ed1a828f622481
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_324d8d8da386c3aaeb0fa63a9e1e9d77
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1c9aa19c1dd57a24e27393b3b1e66c6c |
| publicationDate |
2011-10-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2011123837-A2 |
| titleOfInvention |
Method and system using computer simulation for the quantitative analysis of glycan biosynthesis |
| abstract |
This invention relates to methods and systems for the quantitative analysis of glycan biosynthesis along meta pathways, and more particularly, to using a computer simulation for comparing a computer generated spectrum to experimental data to quantitatively track the biosynthesis. Computer simulating the mass spectra of isotopic detection of aminosugars with glutamine experiments allows modeling the glycan biosynthesis over time, via changes in the 14N and 15N isotope abundance levels, so as to estimate the relative abundance of molecules involved in glycan biosynthesis, from experimental mass spectra collected from different time points. The proposed approach utilizes gradient search optimization to maximize the coefficient of determination between the experimental spectrum and the simulated spectrum. These relative abundances are then fed into a pathway simulation model to analyze glycan biosynthesis. Using a computer for simulating a mass spectrum allows reconfirming the identification, quantifying the isotopic configurations and obtaining the relative abundance of each as samples are taken at periodic intervals. This information can then be organized into time-series data allowing tracking the changes in abundance levels over time. These changes can then be used to analyze the data properties of glycan biosynthesis. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103018317-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109271707-A |
| priorityDate |
2010-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |