| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7450f8b709a8f9c94070d7468a736d31
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3ec4fdcedaecb58a77276de7ece342b3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_91e2cb26955bbd751109d3c35b48a395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_29d0654592afcbcf089c679369443092
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bab6929dd09b2dc86a21bf347adc9559
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_58ec318005987b3f74d1a4ebf35247a0 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-321
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-533
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-334 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-713 |
| filingDate |
2011-03-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_55d3405a7cf68988496be3cee7b03910
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1a07cac140befc16201dddfb27f8297d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f4092987d4ecdf0ee87aa6351be85838
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7659969a607d7d9c82f3050598e4b1f8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a8df46744d1f5edfda8741fc37df0f3a |
| publicationDate |
2011-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2011120023-A1 |
| titleOfInvention |
Nucleic acid compounds for inhibiting survivin gene expression uses thereof |
| abstract |
This disclosure provides double- stranded nucleic acid complexes having one or more hydroxymethyl substituted nucleomonomer(s) and wherein one strand is complementary to a BIRC5 mRNA. Nucleic acid complexes of the disclosure may be useful for therapeutic applications, diagnostic applications or research applications. Nucleic complexes include short interfering RNA complexes (siRNA) capable of modulating gene expression comprising an antisense strand and a continuous or a discontinuous passenger strand ("sense strand"). Further, one or more hydroxymethyl substituted nucleomonomer(s) of this disclosure may be positioned at the 3 '-end, at the 5 '-end, at both the 3 '-end and 5 'end, and/or in a double- stranded region of a nucleic acid complex. Also provided are methods of decreasing expression of a BIRC5 gene in a cell or in a subject to treat a BIRC5-related disease. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10736845-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10561611-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9895313-B2 |
| priorityDate |
2010-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |