| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_81b1af1837003240259e828563f6228e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_96bd489551e50ce9e185444744135f01
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_153c01eeb1875a8a72fb39f4b5bba2ee
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7f49254d7df51c7138ef2fe4dd69badb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7374017bb406cba29f3e1282e1237e39
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ebee13b065212314bbcac0929aa7e3bf |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5073
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5014
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6848 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-00 |
| filingDate |
2011-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aa1f32384f05ffbd3e01297f8969cf68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_87de491b50feb8eb41c473ad3b0b7a20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_62ee4726ea11cba4e6fa44548e090b3d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1f418c2cea06d8cdbad340adeae2a6d5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_719caa638b876a0ed8038607c1280c19 |
| publicationDate |
2015-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2011119637-A9 |
| titleOfInvention |
Predicting human developmental toxicity of pharmaceuticals using human stem-like cells and metabolomics |
| abstract |
The invention provides biomarker profiles of metabolites and methods for screening chemical compounds including pharmaceutical agents, lead and candidate drug compounds and other chemicals using human stem-like cells (hSLCs) or lineage-specific cells produced therefrom. The inventive methods are useful for testing toxicity, particularly developmental toxicity and detecting teratogenic effects of such chemical compounds. Specifically, a more predictive developmental toxicity model, based on an in vitro method that utilizes both hSLCs and metabolomics to discover biomarkers of developmental toxicity is disclosed. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108254467-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108254467-A |
| priorityDate |
2010-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |