| abstract |
Compounds represented by general formula (I) (wherein R 1 represents a C 1-6 alkyl group optionally substituted by 1-3 substituents selected from substituent group A, which consists of hydroxy groups, halogeno groups, cyano groups, nitro groups, amino groups, carboxy groups and C 1-3 alkyl groups; R 2 , R 3 and R 8 each individually represents a hydrogen atom or a C 1-3 alkyl group; R 4 , R 5 , R 6 , R 7 , R 9 and R 10 each individually represents a hydrogen atom or the like; and R 11 represents a hydrogen atom or the like) and pharmacologically-acceptable salts thereof exhibit a TAFIa-inhibiting activity, and thus are useful as therapeutic drugs for myocardial infarction, angina, acute coronary syndrome, cerebral infarction, deep vein thrombosis, pulmonary embolism, etc. |