| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_73e4a790d3e1b297723b38992995a4e5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b0ef0fa4e2293d23710c4f9991300cd8 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4465
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-445
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4453
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-46 |
| filingDate |
2010-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4a56cc26bdfaeb6cccdf58b17c1f7526
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9e56205e2466a2d60b33af2ec9b80e7f |
| publicationDate |
2011-09-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2011114195-A1 |
| titleOfInvention |
Synthesis of propiverine hydrochloride |
| abstract |
The present invention provides a two step esterification process for the synthesis of Propiverine hydrochloride. In the synthetic scheme disclosed herein benzillic acid 1 is directly converted to di-propyl ester ether 7 from the known standard method. The intermediate thus obtained is reacted with N-Methyl 4-hydroxy piperidine in the presence of sodium t-butoxide at room temperature to get Propiverine base 5. This is then finally converted to Propiverine hydrochloride. The process of synthesis provides Propiverine hydrochloride in a very pure form (>99%) with a very good yield. The compound is very useful in treating urinary incontinence. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-4035668-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9896416-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2015524469-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104603108-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108658842-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014025569-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EA-029678-B1 |
| priorityDate |
2010-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |