| abstract |
The present invention provides a novel compound having an excellent antitumor effect. The compound of the present invention is represented by the following general formula (1) wherein R 1 and R 2 are aryl or the like; A is lower alkylene; Ring X is optionally substituted arylene; E is bond or lower alkenylene; Ring Y is optionally substituted heterocycloalkylene containing one or more nitrogen atoms, one of which is attached to the adjacent carbonyl group; G is -NH-G 2 -, -N(lower alkyl)-G 2 -, -NH-CH 2 -G 2 -, -N(lower alkyl)-CH 2 -G 2 - or -CH 2 -G 2 -, [wherein G 2 binds to R 2 , G 2 -R 2 is bond-R 2 , phenylene-G 3 -R 2 , phenylene-G 4 -O-R 2 , phenylene-G 5 -NH-R 2 , phenylene-G 6 -N(lower alkyl)-R 2 or quinolinediyl-O-R 2 , the phenylene of said phenylene-cotnaining groups being optionally substituted with one or more substituents; G 3 -R 2 is -O-lower alkylene-R 2 or the like; G 4 -O- is lower alkylene-O- or the like; G 5 is lower alkylene; G 6 is lower alkylene]. |