| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dc62792656aa2e858252e97e5ffaca79
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a087c36ccc055225bf451a92e1f58a79
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ae7c651a829e30959a265f4464ac5575
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e5c22406337bc4a9ebf0d35307929c73 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-27
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6903
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6921
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-549 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 |
| filingDate |
2011-01-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5d94ac556f12041ea57da0603c0b97a3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9fe1c268d97ea756f791eda983a82083
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eac87bf933ae02a574de433765ce60fa |
| publicationDate |
2011-07-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2011091307-A1 |
| titleOfInvention |
Affinity hydrogels for controlled protein release |
| abstract |
The present invention relates to novel porous matrix composites and formulations for controlled protein delivery and the uses therefor. The present invention also provides methods of synthesizing such protein delivery systems. The composites comprise affinity sites embedded in the matrix where the affinity sites are functionalized with nucleic acid aptamers having high affinity for proteins to be released. The aptamers function as binding affinity sites for the proteins to be released. In certain embodiments, release rates are controlled by tuning the binding affinity of the nucleic acid aptamerd to the proteins at a desired level. In yet other embodiments, complementary oligonucleotides that hybridize with the aptamerd are employed to trigger accelerated release of the proteins when desired. Various in situ injectable hydro gels functionalized with aptamers are provided for treating a condition and disease in a subject in need of a therapeutic protein. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110945340-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110945340-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018055360-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11058632-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110177574-A |
| priorityDate |
2010-01-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |