| abstract |
A compound has Formula VIII where, X is -C(O)R, -C(O)OR, -CN, -NO 2 , -S(O) 2 R', -P(O)(OR) 2 ; each R is individually H, alkyl, or alkenyl; R' is alkyl or akenyl; R 1 is aryl, alkenyl, arylalkenyl, heterocyclyl, or heteroaryl; and R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , and R 11 are individually H, alkoxy, or hydroxy. In some cases, X is NO 2 . Pharmaceutical compositions of the compound of Formula (VIII) with a pharmaceutically acceptable carrier may be prepared. The compounds may be used for inhibition of cyclooxygenase-2. |