| abstract |
Orthomyxovirus small viral RNAs (svRNAs), which regulate the switch between transcription and replication of the Orthomyxovirus genomes, compounds that modulate the expression or activity of svRNAs, and compositions comprising such compounds are disclosed. Also described are methods for treating an Orthomyxovirus, such as an influenza virus, infection or disease or symptom associated therewith, comprising administering to a subject a compound that modulates the expression or activity of svRNAs. Also described are methods for using compounds that modulate the expression or activity of svRNAs to generate attenuated Orthomyxoviruses, such as influenza viruses. Further, described are non-human transgenic animals comprising a nucleic acid compound that modulates the expression or activity of svRNAs stably integrated into the genome of the non-human animals. |