| abstract |
Provided is a novel compound which has a strong AMPK activating action and a favorable effect derived from the AMPK activating action in vivo , and further provided is a drug which is structurally novel and highly effective, long-acting, and safe as a type II diabetes drug. As a result of focusing on the specific role of human AMPK in energy metabolism in order to create a drug that is structurally novel and highly effective, long-acting, and safe as a type II diabetes drug, it was discovered that the novel benzylparabanic acid derivative represented by general formula (1) and addition salts thereof have an excellent human AMPK activating action and an excellent blood glucose-lowering action and lipid-lowering action in vivo . |