| abstract |
A method of enhancing the expression of human papillomavirus (HPV) L1 in various expression systems, in particular by producing a chimaeric polypeptide with improved expression levels relative to the native polypeptide, is described. The expression system may be an insect, animal, plant or yeast system. Furthermore, chimaeric nucleotide and polypeptide sequences are described, and expression vectors comprising chimaeric nucleotide sequences. A pharmaceutical composition comprising a chimaeric HPV L1 made according to the invention and a method of treating or preventing an HPV infection or cervical cancer in a subject is also described. |