http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011074717-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4a660dba4321ea506c7a4fb95bf3f1e3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_babc260aae58abdcaf6ea38980c758a6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dcca5ba31295816e52ae4f5fba91a297 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-1075 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-026 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6829 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-14 |
| filingDate | 2009-12-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c52f695839ee4b44ab0cd24940f799ba http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6f073e39e81e327ccc698f4f644383df http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4ca0b4bbfa0870890f518457c0b184c0 |
| publicationDate | 2011-06-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2011074717-A1 |
| titleOfInvention | Method for manufacturing dimers and multimers by increasing the production of bond bridges in a complex of multiple monomers and repeating chains of an adherend of a type specifically adhering to monomers |
| abstract | The present invention relates to a method for manufacturing multimers in which a plurality of monomers are linked by bond bridges, by making repeating chains comprising repeatedly linking adherends of a type specifically adhering to monomers, and by using the same to create a repeating chain/multiple-monomer complex created from the repeating chains and a number of monomers, thereby facilitating the formation of bond bridges between the monomers in the complex. More specifically, the present invention relates to a method for manufacturing multimers in which a plurality of monomers are linked by bond bridges, by making a repeating-chain recombinant protein resulting from the repeated linking of an adherent protein of a type specifically adhering to protein monomers, and by using the same to create a repeating chain/multiple-monomer complex created from the repeating chains and a number of monomers, thereby facilitating the formation of bond bridges between the monomers in the complex. More specifically, the present invention relates to a method for manufacturing multimers in which a plurality of monomers are linked by disulphide bond bridges, by making a repeating-chain recombinant protein resulting from the repeated linking of an adherent protein of a type specifically adhering to protein monomers, and by using the same to create a repeating chain/multiple-monomer complex created from the repeating chains and a number of monomers, thereby facilitating the formation of disulphide bond bridges between the monomers in the complex. More specifically, it relates to a method for manufacturing dimers and multimers in which a plurality of monomers are linked by disulphide bond bridges, by creating repeating chains, and multi-monomer complexes thereof, from monomers of an antibody protein through the use of a skeleton comprising a recombinant repeating chain protein resulting from the repeated linking of the domain III (the Fab adhering domain) of Streptococcal protein G, thereby facilitating the formation of disulphide bond bridges between the monomers in the complex. The method of the present invention can be used to advantage in the large-volume manufacture of disulphide bond bridge dimers since it gives up to a 200 fold improvement in the yield of disulphide bond bridge dimers as compared with known refolding methods of the prior art. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9862778-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10626189-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10428120-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11725065-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2014529997-A |
| priorityDate | 2009-12-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 95.