| abstract |
The invention relates to a method for the manufacture of 5-[2-cyclopropyl-l-(2- fluorophenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate hydrochloride of formula I (prasugrel hydrochloride) in crystalline form B, wherein prasugrel base of formula II is dissolved or suspended in an organic solvent and reacted with hydrogen chloride dissolved in an organic solvent or in water at a temperature in the range of -20 °C to 75°C and crystallized, optionally after addition of a co-solvent. |