| abstract |
The present invention relates to a crystal of the protein thymidylate synthase (TS), in particular human TS, in the presence of a ligand, methods of crystallization thereof and uses thereof. The invention also relates to the three- dimensional structure of a new binding site located in the dimerization interface region of TS protein and applications thereof in the design and obtainment of new inhibitors with pharmacological activity, in particular antitumour activity. |