| abstract |
Provided is a three-step method for manufacturing optically active 3-tert-butoxycarbonylamino-2-fluoro-1-propanol. The provided method can dramatically reduce the amount of a palladium catalyst used and can complete the reaction in one cycle, thereby reducing manufacturing costs and simplifying the procedure. Furthermore, the final target substance is crystallized and purified through recrystallization, yielding a high-purity result. Also provided is optically active 3-tert-butoxycarbonylamino-2-fluoropropionic acid ester, a novel substance which is a key intermediate in the provided manufacturing method. |