http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011060205-A1

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publicationDate 2011-05-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2011060205-A1
titleOfInvention Methods, compositions, and assays for determining the effect of an immune cell on a cell from an infectious or neoplastic disease
abstract An in vitro assay is provided for determining the effect of an immune cell on a cell from an infectious or neoplastic disease. Also provided is an in vitro assay for determining the effect of an activated CD8 + T-cell on a sensitized melanoma cell. A method for improving the specific cytolytic activity (SCA) of an immune cell comprising contacting an immune cell with an antigen and an antigen-independent pro-inflammatory agent is provided. A method for ex vivo expansion of antigen-specific CD8 + T -cells with enhanced specific cytolytic activity (SCA) comprising culturing the antigen-specific CD8 + T-cells in a suitable culture media comprising an amino acid. An in vitro assay is provided for determining the effect of an immune cell on a cell from an infectious or neoplastic disease. A method of treating a subject suffering from an infectious or neoplastic disease with immuno therapy is described.
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