| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_eea9ff9b3b6c503624032399e557dc9d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4e4c066b3d8185874e461e8305530fe4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fe8ceaf890b41ffa56f96df542e6ec40 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-075
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0362
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-4703
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-042 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0275
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5088 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027 |
| filingDate |
2010-11-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_30bcce88f3ed1bf3cd618f70fd5a5f92
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4e0ac6d396b2a11876fd9e481dd2bfb8 |
| publicationDate |
2011-05-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2011058994-A1 |
| titleOfInvention |
Nonhuman animal model of type 2 diabetes |
| abstract |
Provided is a novel nonhuman animal model of type 2 diabetes which spontaneously causes a pathology similar to nonobese type 2 diabetes common among Japanese people, wherein the function of the Cdkal1 gene is specifically suppressed on the chromosome of the pancreas β cell. Specifically, the nonhuman animal model of type 2 diabetes may be prepared by mating: a nonhuman animal having a site-specific recombinase-recognition sequence on the 3'-untranslated region and the 5'-untranslated region of a predetermined region containing one or more exons in the Cdkal1 gene; and a nonhuman animal in which a site-specific recombinase gene which recognizes the aforementioned site-specific recombinase-recognition sequence, and can cutout the aforementioned predetermined region is inserted in a manner so as to be able to express on the downstream of the promoter of a gene that specifically expresses in the pancreas. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014156196-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-WO2014156196-A1 |
| priorityDate |
2009-11-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |