| abstract |
Disclosed is a novel and excellent prophylactic and/or therapeutic method for diseases associated with interleukin-1 receptor-associated kinase-4 (IRAK-4), which is based on an interleukin-1 receptor-associated kinase-4 (IRAK-4) inhibitory effect. Specifically disclosed is an oxazole carboxylic acid amide derivative which is characterized in that an oxazole that is substituted with a heteroaryl group at the 2-position is bonded to a heteroaryl ring via a carboxamide. The oxazole carboxylic acid amide derivative has a strong inhibitory effect on IRAK-4, and can serve as a prophylactic and/or therapeutic agent for diseases associated with IRAK-4 such as inflammatory diseases and autoimmune diseases. |