| abstract |
The invention relates to compounds of Formula (I): (A') x -(A)-(B)-(Z)-(L)-C(=O)NH 2 or pharmaceutically acceptable salts or solvates thereof, wherein: (A) is heteroaryl or aryl; each (A'), if present, is indepedently chosen from aryl, arylalkoxy, arylalkyl, heterocyclyl, aryloxy, halo, alkoxy, haloalkyl, cycloalkyl, haloalkoxy, and cyano, wherein each (A') is substituted with 0, 1, 2 or 3 substituents independently chosen from halo, haloalkyl, aryl, arylalkoxy, alkyl, alkoxy, cyano, sulfonyl, sulfinyl, and carboxamide; X is 0, 1, 2, or 3; (B) is a cyclopropyl ring, wherein (A) and (Z) are covalently bonded to different carbon atoms of (B); (Z) is -NH-; and (L) is -(CH 2 ) m CR 1 ,R 2 -, wherein m is 0, 1, 2, 3, 4, 5, or 6, and wherein R 1 and R 2 are each independently hydrogen or C 1 -C 6 alkyl; provided that, if (L) is -CH 2 - or -CH(CH 3 )-, then X is not 0. The compounds of the invention are useful in the treatment of diseases such as cancer and neurodegenerative diseases. |