| abstract |
By modifying an amino acid sequence, an antibody constant region capable of enhancing the agonistic activity of an antibody was successfully provided. More specifically, it was discovered that an antibody, which had a constant region having substitution or deletion of an amino acid in the antibody heavy chain constant region, or an antibody, which had a constant region having substitution of an amino acid in the hinge region, showed enhanced agonistic activity. By using these antibodies in medicinal preparations, medicinal preparations having improved performance can be provided. |