| abstract |
The invention provides specific binding proteins and the uses thereof. Particularly, the invention provides a monoclonal antibody which can effectively bind to the class III variant of the epidermal growth factor receptor (EGFRvIII) or can partially bind to the epidermal growth factor receptor (EGFR) over-expressed in cells, but can not bind to EGFR normal-expressed in cells. Furthermore, the present antibody is efficacious against tumor cell lines expressing EGFRvIII. The invention also provides a method for manufacturing said monoclonal antibody and a pharmaceutical composition comprising said monoclonal antibody. |