| abstract |
The present invention relates to pharmaceutical compositions for preventing or treating osteoporosis, which comprise bisphosphonate-based compounds such as risedronic acids or the salts thereof, ibandronic acids or the salts thereof, or the like, and high-dose cholecalciferol, and which are to be administered once a month. The present invention also relates to pharmaceutical compositions for preventing or treating osteoporosis to be administered once a month, comprising: (a) cholecalciferol-containing granules obtained by adsorbing, to microcrystalline cellulose, the solution obtained by dissolving, into ethanol or an aqueous ethanol solution: (i) 24,000 to 50,000 IUs of cholecalciferol; (ii) one or more first stabilizers selected from among tocopheryl acetate, butylated hydroxytoluene and butylated hydroxyanisole; and iii) a binder; (b) mannitol as a second stabilizer; and (c) risedronic acids or the salts thereof or ibandronic acids or the salts thereof. |