| abstract |
Provided is a means for expressing/presenting a protein on the cell surface of a Bifidobacterium. The provided gene to be expressed on the surface of a Bifidobacterium comprises a gene that codes for a Bifidobacterium-derived GNB/LNB substrate-binding membrane protein and a gene that codes for a target protein or peptide, joined in that order from the 5สน end. Thus, a transformed Bifidobacterium into which the provided gene to be expressed on the surface of a Bifidobacterium has been introduced expresses the target protein or peptide on its surface. If the target protein or peptide is an antigen protein or an antigen peptide, the transformed Bifidobacterium is useful as an oral vaccine. |