| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_23831bf7f3bb248223841fad1b6cf28d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_668a585b14b86cb9d3b8f23296504590
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b92845b5ae5d965a19628316b33821c3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fb0ac0f0b1c1833e284beae29a13b02b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bb1f5a047939f83cce008b654f7fdc8c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4422d7d52773edb922faa4aceef1b225
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_101416daec91d230984e7ff56848eadd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_58828c5f13dc615912c42d7c91459d51
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b8b5a3165872f649f602adb8fc72986d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_173db2cbb82ae9a89f7c061c29018e7f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7ec9258656a4a24c4bcd2bd6c1fd3015 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2760-16134 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-145
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-005 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-145
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-11 |
| filingDate |
2010-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_23053907351826931298320158623b53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_02a329ff1a4eea8a6809b75055d22e33
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a8feaf84a989b22ef39c1f4c58a005c3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4ec506fea14776d31fb9aa6a67a3e0f1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_806d5236ada9d6a25f51ac3c6179b470
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_89687a1420505c2450812a2452e45288
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a3966c9ddc3d274b774b6f51f8b36bd4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9391227bfefd3438e55301272fa17d00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d16f29a984e6cf9c4da932b54ffc1bdf
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9365958a4d9ad88e4ab6b166150b73d2 |
| publicationDate |
2011-03-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2011031125-A1 |
| titleOfInvention |
Recombinant proteins that can be expressed in escherichia coli as active ingredients of vaccines against 2009 outbreak h1n1 influenza a, and production method thereof |
| abstract |
The present invention relates to a group of recombinant proteins (generally referred to in the present document as HA 50-274 -H1N1) which can be expressed in E. coli , which contain a hemagglutinin (HA) fragment of the H1N1/2009 influenza A virus in the sequence thereof and which exhibit immunogenic and protective activity against influenza infection in mammals. This fragment corresponds to the region between amino acid 50 and amino acid 274 of H1N1/2009 influenza A virus hemagglutinin (SEQ ID No. 1). The invention also relates to a plurality of clones capable of expressing said group of immunogenic and protective proteins, for example clones such as E. coli BL21 (DE3) pLysS C41 deposited at the ATCC ® under patent deposit designation PTA-10320. The invention further relates to the use of said proteins as vaccines or ingredients in formulations for vaccines against H1N1/2009 influenza A infection or seasonal influenza infection. In addition, the invention relates to a method whereby HA 50-274 -H1N1 protein variants can be produced with a suitable level of biological activity (specific recognition of human serum antibodies in patients convalescing from H1N1/2009 influenza A, specific immunogenic activity in mammals, protective activity in mammalian cell cultures and animal models) and a sufficient level of purity for industrial use. |
| priorityDate |
2009-09-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |