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publicationDate 2011-03-03-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2011023734-A1
titleOfInvention Process for the precipitation of inhalable pharmaceutical agents in the propellant
abstract A process for providing a dispersion of a pharmaceutical product in a liquefied gas propellant in a metered dose inhaler comprising preparing a supercritical solution of the pharmaceutical product dissolved in the propellant in a supercritical fluid state then reducing the temperature and pressure of the supercritical solution to respectively below T n c and below p n c to precipitate the pharmaceutical product and provide a dispersion of the pharmaceutical product in the liquefied propellant; then charging the dispersion to the canister of an MDI.
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