http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011022820-A1

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filingDate 2010-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_665d6d1b70b20ffa51f188eb527ecaa1
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publicationDate 2011-03-03-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2011022820-A1
titleOfInvention Binding-induced hairpin detection system
abstract This application relates to a binding-induced hairpin detection system comprising: a. a first probe comprising a targeting molecule and an oligonucleotide that has a free end and an end attached to the targeting molecule; and b. a second probe comprising a targeting molecule and an oligonucleotide that has an end attached to the targeting molecule and a free end comprising a nucleotide sequence that is complementary to a nucleotide sequence at or near the free end of the oligonucleotide of the first probe; wherein upon binding of the targeting molecule to a target molecule, the free end of the oligonucleotide of the second probe hybridizes at or near the free end of the oligonucleotide of the first probe forming a hairpin stem, the non-hybridized portions of the first and second probes together with the target molecule bound thereto forming a hairpin loop, thereby providing a binding-induced hairpin.
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