| abstract |
The present invention relates to the roles played by a CSTF2 gene in cancer carcinogenesis and features a method for treating or preventing cancer by administering a double-stranded molecule against the CSTF2 gene or a composition, vector or cell containing such a double stranded molecule. The present invention also features methods for diagnosing cancer or assessing/determining the prognosis of a subject with lung cancer, using the over-expressed CSTF2 gene. To that end, CSTF2 may serve as a novel prognosis biomarker for cancer, particularly lung cancer. Also, disclosed are methods of screening candidate substances for treating and preventing cancer, using as an index their effect on the expression or biological activity of CSTF2. |